ARA-290 - 10mg - 3ml

11 amino acid peptide derived from helix B of erythropoietin, engineered to retain EPO's tissue protective signaling without its effect on red blood cell production. ARA-290 selectively activates the innate repair receptor, a receptor complex that appears on tissue only in response to injury or inflammatory stress, meaning activity concentrates where damage is present rather than acting systemically. Signaling through this pathway dampens inflammatory cytokine output including TNF-alpha and IL-6, reduces cell death in stressed tissue, shifts macrophages toward a reparative state, and supports regrowth of damaged small nerve fibers. Clinical research has centered on small fiber neuropathy in sarcoidosis and type 2 diabetes, with published work showing measurable increases in corneal nerve fiber density alongside improvement in pain and autonomic symptom scores. Interest also extends to metabolic support, post injury recovery, and neuropathic and inflammatory conditions where inflammation and nerve damage overlap.